Combining the effects of physical (medical microneedling) and chemotactical, yet biological (prp-treatment) cellular stimulation, plasma needling is already offeredby Dr. Huschek since 2012 at his private practice in Hamburg to a clientel of international patients. Furthermore, there is currently no other way of applying the autologous platelet-derived growth factors to the layers relevant for regeneration of the skin in a similar consistent manner. Plasma needling, as well as PRP-therapy and medical microneedling, should be performed in a strictly sterile modus operandi to prevent the only possible sideeffect, an infection by contamination. Both treatments alone already proofed significant results in clinical trials. Links to PUBMED-listed relevant scientific publications are provided below:
Fabbrocini G, De Vita V, Pastore F, Annunziata MC, Cacciapuoti S, Monfrecola A, Cameli N, Tosti A. Collagen induction therapy for the treatment of upper lip wrinkles. J Dermatolog Treat. 2012 Apr;23(2):144-52. doi: 10.3109/09546634.2010.544709. Epub 2011 Aug 2. PMID: 21810012
Imran Majid: Microneedling Therapy in Atrophic Facial Scars: An
Objective Assessment. J Cutan Aesthet Surg. 2009 Jan-Jun; 2(1): 26–30. doi: 10.4103/0974-2077.53096 PMCID: PMC2840919
Horst Liebl and Luther C. Kloth, PT, MS, FAPTA, CWS, FACCWS: Skin Cell Proliferation Stimulated by Microneedles. J Am Coll Clin Wound Spec. Mar 2012; 4(1): 2–6. Published online Dec 25, 2012. doi: 10.1016/j.jccw.2012.11.001 PMCID: PMC3921236
Ramos-Torrecillas J, Luna-Bertos Ed, Manzano-Moreno FJ, García-Martínez O, Ruiz C.: Human fibroblast-like
cultures in the presence of platelet-rich plasma as a single growth factor source: clinical implications. Adv Skin Wound Care. 2014 Mar;27(3):114-20. doi: 10.1097/01.ASW.0000443266.17665.19. PMID: 24531517
Yuksel EP, Sahin G,
Aydin F, Senturk N,
Turanli AY.: Evaluation of effects of platelet-rich plasma on human
facial skin. J Cosmet Laser Ther. 2014 Oct;16(5):206-8. doi:
10.3109/14764172.2014.949274. Epub 2014 Aug 25. PMID: 25065381
Nofal E, Helmy A,
Nofal A, Alakad R,
Nasr M.: Platelet-rich plasma versus CROSS technique with 100%
trichloroacetic acid versus combined skin needling and platelet rich plasma in the treatment of atrophic acne scars: a comparative study.Dermatol
Surg. 2014 Aug;40(8):864-73. doi: 10.1111/dsu.0000000000000091. PMID: 25006854
Cervelli V, Garcovich S, Bielli A, Cervelli G, Curcio BC, Scioli MG, Orlandi A, Gentile P.: The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric
evaluation. Biomed Res Int. 2014;2014:760709. doi: 10.1155/2014/760709. Epub 2014 May 6.
PMID:
24883322
Fabi S, Sundaram H.: The potential of topical and injectable growth factors and cytokines for skin rejuvenation. Facial Plast Surg. 2014 Apr;30(2):157-71. doi: 10.1055/s-0034-1372423. Epub 2014 May 8. PMID: 24810127
Following the indications and contraindications, the risk of side effects is low. Since no artificial substances are used for plasma needling, the only side effects possible are bruising and infection, while the latter can be prevented by a strictly sterile modus operandi.